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KMID : 0363219650040010031
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Korean Journal of Dermatology
1965 Volume.4 No. 1 p.31 ~ p.38
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Antifungal Effects of Griseofulvin to Various Dermatophytes
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卞東吉/Byun, Dong Kil
徐治均/宋浚榮/南龍鎭/申鉉喆/Suh, Chi Kyun/Song, Joon Young/Nam, Yong Jin/Shin, Hyun Chul
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Abstract
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Although there have been many reports concerning the antifungal effects with various dermatophytes, there has been no such report in Korea. Authers investigated to know the characteristics of main pathogenic species of dermatophytes to griseofulvin in Korea, particulary the T. ferrugineum to which no any griseofulvin sensitivity test has been made hr literature.
Griseofulvin sensitivity test in vitro and elementary changes of the dermatophytes on the hanging drop culture were observed on total 81 strains isolated from dermatophytosis, consisting of 61 strains of T.ferrugineum, 6 strains of T.rubrum, 2 strains of T. mentagrophytes, 2 strains of T. gypseum, 4 strains of M. canis and 6 strains of E. floccosum, and the following results were obtained.
1) T. ferrugineum and E. floccosum were the most sensitive, T. rubrum and M. canis were moderate, and T. gypseum and T. mentagrophytes were least to griseofulvin.
2) Griseofulvin inhibited the growing hyphae moderately at even the minimum concentration of 0. 122 mcg/ml,
3) All examined fungal hyphae were inhibited to grow by griseofulvin and formed the powdery spores macroscopically,
4) Variations of the hyphae such as shortening, curling, swelling, degeneration, clumping, and septation were observed microscopically with arthrospores and microconidia which was rather smaller than normal in size.
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